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What is tapentadol? Tapentadol is an opioid ache medication. An opioid is sometimes referred to as a narcotic. Tapentadol is used to deal with reasonable to severe pain. The extended-release shape of tapentadol (Nucynta ER) is for around-the-clock cure of pain that is not managed via different medicines. Nucynta ER is no longer for use on an as-needed basis for pain. Important Information Do now not use tapentadol if you have used a MAO inhibitor in the past 14 days. A hazardous drug interplay may want to occur. MAO inhibitors encompass isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. You have to now not use this remedy if you have extreme breathing problems, or a bowel obstruction known as paralytic ileus. Tapentadol can slow or quit your breathing, mainly when you start the use of this medicinal drug or every time your dose is changed. Never take this medication in large amounts, or for longer than prescribed. Do n